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Background
The outcomes for patients with diffuse large B‐cell lymphoma (DLBCL) with adverse clinical prognostic factors such as a high age‐adjusted International Prognostic Index (aaIPI) are not optimal. In the current study, the authors performed a systematic review and meta‐analysis to assess the totality of evidence pertaining to the efficacy of autologous hematopoietic stem cell transplantation...
Background
The incidence of oropharynx cancers has increased substantially in the United States. However, risk stratification tools for the identification of high‐risk individuals do not exist. In this study, an individualized risk prediction model was developed and validated for oropharynx cancers in the US population.
Methods
A synthetic, US population–based case‐control study was conducted....
Background
An association between a nonmedicinal herbal diet and nasopharyngeal carcinoma (NPC) has often been hypothesized but never thoroughly investigated.
Methods
This study enrolled a total of 2469 patients with incident NPC and 2559 population controls from parts of Guangdong and Guangxi Provinces in southern China between 2010 and 2014. Questionnaire information was collected on the intake...
Background
Although the benefits of palliative care for patients with cancer has been well established, the current utilization pattern remains largely unknown. The authors investigated the temporal trends and service settings of palliative care among Medicare beneficiaries with newly diagnosed, metastatic non–small cell lung cancer (NSCLC).
Methods
In total, 69,414 patients with NSCLC were identified...
Background
Sleep disturbance and genetic profile are risks for cognitive decline in noncancer populations, yet their role in cancer‐related cognitive problems remains understudied. This study examined whether sleep disturbance was associated with worse neurocognitive outcomes in breast cancer survivors and whether sleep effects on cognition varied by genotype.
Methods
Newly diagnosed female patients...
Background
Although general trends in cancer outcomes are improving, racial/ethnic disparities in patient outcomes continue to widen, suggesting disparity‐related shortcomings in cancer research designs.
Methods
Using convenience sampling, a total of 24 data sources, representing several research designs and 5 high‐burden tumor types, were included for analyses. The percentages of races/ethnicities...
Background
Bladder cancer (BCa) can be divided into muscle‐invasive BCa (MIBC) and non−muscle‐invasive BCa (NMIBC). Whether the tumor infiltrates the detrusor muscle is a critical determinant of disease management in patients with BCa. However, the current preoperative diagnostic accuracy of muscular invasiveness is less than satisfactory. The authors report a radiomic‐clinical nomogram for the individualized...
Background
Randomized trials have reported conflicting findings on survival for advanced‐stage ovarian cancer treated with primary debulking surgery (PDS) versus neoadjuvant chemotherapy with interval debulking; surgical complications and mortality are higher with PDS. We assessed women's preferences for tradeoffs related to this important clinical decision.
Methods
Ovarian cancer patients were...
Background
The concurrent use of opioids with benzodiazepines (BZD) or nonbenzodiazepine sedatives (S) recently was found to be associated with an increased risk of overdose death compared with the use of opioids alone. In the current study, the authors examined the frequency and trend of concurrent opioid/BZD‐S use and its associated risk factors among patients with cancer.
Methods
Data regarding...
Background
Although multiple co‐occurring symptoms are a significant problem for cancer survivors, to the authors' knowledge little is known regarding the phenotypic characteristics associated with a higher symptom burden. The objectives of the current study were to evaluate the occurrence, severity, and distress associated with 32 symptoms and examine the phenotypic and stress characteristics associated...
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